弱酸对病原性病毒的pH取决于病毒杀伤作用
Weiyin Hu1, Hiroshi Shimoda1, Yoshihiro Tsuchiya2
1Laboratory of Veterinary Microbiology, Joint Graduate School of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8511, Japan.
Tropical medicine and health
|January 11, 2024
概括
像酸这样的弱酸对病毒有不同的杀毒作用,不仅仅取决于pH值. 某些富含酸的,可以在家中消毒包装的病毒.
科学领域:
- 病毒学 病毒学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 弱酸具有病毒杀伤性,可能与质子度和低pH值有关.
- 消毒剂的有效性可能源于它们的酸性.
- 这项研究调查了弱酸和对各种病毒的疗效.
研究的目的:
- 为了评估酸,酸和酸在不同pH值下的杀菌效果.
- 评估白蒸 (WDV) 和有谷物风味的蒸 (GV) 的失活能力.
- 为了比较对包裹病毒 (流感A病毒,SARS-CoV-2) 和非包裹病毒 (猫病毒) 的影响.
主要方法:
- 弱酸 (酸,酸,酸) 被调整到pH值为2,4和6.
- 酸被连续稀释,从1M稀释到0.001M.
- 包裹病毒 (流感病毒A,SARS-CoV-2) 和非包裹病毒 (猫病毒) 用酸和治疗长达30分钟.
主要成果:
- 在pH 4下,乙酸会使A型流感病毒失活;而酸和酸则不会.
- 酸和酸在pH 2时使SARS-CoV-2无活化;氧酸没有.
- 所有酸都在pH 2时不活性化猫类卡利西病毒,但不是pH 4时.
- 在30分钟内,WDV和GV迅速降低了流感A病毒标位,并使SARS-CoV-2失活.
- WDV和GV并没有显著地禁用猫类卡利西病毒.
结论:
- 弱酸的杀菌效果受到超出pH值的因素的影响.
- ,主要是酸,在家庭环境中显示出对包裹病毒的消毒剂的潜力.
- 特定的酸和病毒类型决定了失活的有效性.
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