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N-cadherin:一种诊断标志物,有助于区分原发性肝癌与肝外癌

Tiemo S Gerber¹, Dirk A Ridder¹, Benjamin Goeppert^2,3

¹Institute of Pathology, University Medicine, Johannes Gutenberg-University, Mainz, Germany.

International journal of cancer

|January 12, 2024

概括

N-cadherin表达有助于区分原发性肝癌 (PLC) 和肝转移. 这种糖蛋白在肝细胞癌 (HCC) 和肝内胆管癌 (iCCA) 中高度表达,有助于差异诊断.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
癌症的诊断癌症的诊断

背景情况:

从临床上来说,区分原发性肝癌 (PLC) 和肝转移是非常重要的,但从基因病理上来说,这是非常具有挑战性的.
通常在大多数上皮细胞中不存在的N-cadherin通常仅限于神经/介质细胞或经历表皮细胞到介质细胞过渡 (EMT) 的细胞.
最近的发现确定了N-和E-cadherin作为正常肝细胞和胆血管细胞的标志,在HCC和iCCA中保存.

研究的目的:

调查E-和/或N-cadherin表达是否可以区分原发性肝癌与其他来源的癌症.
评估N-cadherin作为原发性肝癌与肝转移的潜在诊断标志物.

主要方法:

一个多中心研究利用免疫组织化学来评估E-和N-cadherin表达.
对3359个不同瘤样本的分析,与之前发表的882个PLC病例 (570个HCC,312个iCCA) 相比.

主要成果:

大多数癌症都表现出强烈的E-cadherin阳性.
肝细胞癌 (HCC) 和肝内胆管癌 (iCCA) 显示出强烈的N-cadherin阳性.
与神经内分泌瘤,黑色素瘤和间皮瘤不同的是,N-cadherin在少数非肝脏外肝癌中仅表达微弱.

结论:

N-cadherin表达是区分原发性肝癌 (PLC) 和肝外转移的重要标志物.
N-cadherin的差异性表达模式支持其在提高肝癌诊断准确性的作用.

关键词:

坚持结合结合坚持结合在Cadherin的基础上.未知初级原发性癌瘤的癌症.免疫组织化学免疫组织化学原发性肝癌是一种肝癌.

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