在心力衰竭的老年患者中,使用双能量X射线吸收度和预测模型预测萨尔科佩尼亚的预后
Hiroshi Saito1, Yuya Matsue2, Daichi Maeda2
1Department of Rehabilitation, Kameda Medical Center, Kamogawa, Chiba, Japan.
ESC heart failure
|January 12, 2024
概括
双能X射线吸收计 (DEXA) 诊断的肉症预测了老年心力衰竭患者的死亡率. 萨科佩尼亚的预测方程在这个队列中没有显示出预后价值.
科学领域:
- 老年学是指老年学的学科.
- 心脏病学 心脏病学
- 营养科学 营养科学
背景情况:
- 标志着骨肌肉质量和功能的损失的萨尔科佩尼亚,在心力衰竭 (HF) 的老年人中很普遍.
- 对心力衰竭患者的风险分层和管理来说,准确诊断缩症至关重要.
- 双能X射线吸收度 (DEXA) 是身体组成分析的黄金标准,但预测方程提供了更容易获得的替代方案.
研究的目的:
- 为了比较通过DEXA诊断的肉类的预后值与因心力衰竭住院的老年患者的预测方程.
- 评估DEXA定义的肉类和预测方程衍生的肉类与所有原因死亡率的关联.
主要方法:
- 分析了269名因心力衰竭住院的老年患者 (≥65岁) 的队列.
- 使用DEXA测量尾骨肌肉质量 (ASM),并通过两个预测方程 (人类-ASM和预测-ASM) 估计.
- Sarcopenia 的定义是使用 Asian Working Group for Sarcopenia 2019 的标准进行的. 全因死亡率是主要终点,随访时间中位数为690天.
主要成果:
- 麻症的患病率有所不同:DEXA (49.8%),人体测量-ASM (63.6%),预测-ASM (58.4%).
- 在调整后,DEXA诊断的肉与所有原因死亡率 (HR,2.33;P=0.007) 有显著的关联.
- 通过预测方程 (人类测量-ASM和预测-ASM) 确定的肉类症与死亡率没有显著相关 (P>0.123对两者来说).
结论:
- 通过DEXA诊断的肉类是老年心力衰竭患者预后不良和全因死亡率的重要预测因素.
- 目前用于估计肉症的预测方程在这种特定患者群体中缺乏预后价值.
- 在心力衰竭管理中,DEXA仍然是一个有价值的工具,用于识别患有肉类的高风险个体.
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