相关实验视频
Updated: Jun 27, 2026

06:40
Simple and Computer-assisted Olfactory Testing for Mice
Published on: June 15, 2015
10.1K
通过监督机器学习评估的COVID-19感染对嗅觉功能的诊断和主观感知长期影响
Jörn Lötsch1,2, Oskar Brosig3, Jana Slobodova4
1Goethe-University, Institute of Clinical Pharmacology, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Chemical senses
|January 12, 2024
概括
在COVID-19幸存者的长期嗅觉功能显示出积极的预后. 虽然客观测试显示没有显著的COVID-19影响,主观的自我意识和parosmia可以表明过去的感染.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 感官科学 感官科学
背景情况:
- 嗅觉丧失是2019年冠状病毒疾病 (COVID-19) 的常见急性症状之一.
- 鉴于大流行病的持续时间,评估COVID-19后的长期嗅觉预后至关重要.
研究的目的:
- 评估COVID-19患者的长期嗅觉功能.
- 调查客观的嗅觉诊断和COVID-19后的主观自我感知之间的差异.
主要方法:
- 一项涉及722名参与者 (464名先前患有COVID-19) 的研究通过气味值和识别测试评估了嗅觉功能.
- 参与者还在数值尺度上自我评价了他们的嗅觉功能.
- 监督机器学习算法被用来分析数据.
主要成果:
- 客观的嗅觉诊断类别和测试分数在前COVID-19患者和对照人群之间没有显著差异.
- 前COVID-19患者表现出对嗅觉功能的主观感知变化,包括自我意识降低和帕洛斯米亚.
- 机器学习模型成功地根据主观的嗅觉自我意识识别了过去的COVID-19感染,而不是客观的测试结果.
结论:
- 根据客观措施,COVID-19后的长期嗅觉损失似乎具有积极的预后.
- 嗅觉的主观自我感知,特别是自我意识和的改变,可以作为过去COVID-19感染的指标.
- 未来的研究应该利用验证的诊断措施来调查COVID-19对嗅觉的长期影响.
相关概念视频
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...

