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植物化学物质作为潜在的分子对抗肝细胞癌

Tennyson Prakash Rayginia^1,2, Chenicheri Kizhakkeveettil Keerthana^1,2, Sadiq Chembothumparambil Shifana³

¹Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695014, India.

Current medicinal chemistry

|January 12, 2024

概括

植物化学物质显示出对抗肝癌 (肝细胞癌) 的承诺. 本综述探讨了天然化合物作为潜在的替代品或补充当前治疗这种日益增长的全球健康问题.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
肝病学肝病学是一种肝病学.

背景情况:

肝细胞癌 (HCC) 是最常见的肝癌,导致显著的死亡率.
关键的危险因素包括病毒性肝炎 (B和C),肝硬化和与代谢综合征相关的非酒精性脂肪肝炎.
全球HCC发病率正在上升,预计到2025年将超过100万例.

研究的目的:

审查主要的植物化学物质,研究它们对HCC的抗癌作用.
突出这些天然化合物作为替代或补充疗法的潜力.
提供临床前发现,作用机制和分子点的概述.

主要方法:

关于植物化学品和HCC的科学研究的文献综述.
对疗效和安全的临床前数据的分析.
检查分子点和作用机制的研究.

主要成果:

几种植物化学物质在临床前研究中显示出显著的抗癌活性.
这些化合物表现出与HCC治疗相关的多种生物活性.
作用机制和分子标正在被阐明.

结论:

植物化学物质是新型HCC治疗策略的一个有希望的领域.
进一步的研究可能会导致它们单独或与常规疗法一起被纳入临床实践.
自然化合物为管理日益增长的全球肝癌负担提供了潜力.

关键词:

肝癌是一种肝癌.细胞信号传输的信号.化学预防药物化学预防药物化学敏感化化学敏感化化学疗法药物化学疗法药物肝细胞癌.肝细胞癌.

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