和多基基物质对怀孕和儿童发育的影响
Thanuja Kilari1, Ankul Singh Suresh1, Rukaiah F Begum1
1Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur-603209, Tamil Nadu, India.
Current pediatric reviews
|January 12, 2024
概括
孕妇在怀孕期间接触PER和多基基物质 (PFAS) 与儿童肥胖有关. PFAS会破坏胎盘健康和儿童发育,影响体重指数,并可能导致长期健康问题.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 发育儿科 发育儿科
背景情况:
- 孕产妇暴露在Per和多基物质 (PFAS) 中,对儿童发育的担忧日益加剧.
- 暴露于PFAS与儿童的脂肪增加和潜在的健康风险有关.
- 关联母亲PFAS水平与儿童肥胖的确切机制需要进一步阐明.
研究的目的:
- 审查和多基物质 (PFAS) 暴露对超重和肥胖儿童的影响.
- 探索PFAS在孕妇及其后代的作用的潜在机制.
- 综合有关母亲PFAS度与儿童肥胖之间的关系的当前知识.
主要方法:
- 使用主要科学数据库进行了全面的文献审查.
- 审查的重点是研究PFAS对母亲和儿童健康的影响,包括神经结果的研究.
- 分析包括体外和体内研究,以及人类流行病学数据.
主要成果:
- 暴露于PFAS会破坏胎盘健康和儿童生长,对体重指数产生负面影响.
- 试验室和体内研究表明,PFAS诱导的脂肪生成和通过PPAR-γ和ER-α激活体重增加.
- 孕产妇血清PFAS度与不良儿童健康结果呈正相关性.
结论:
- PFAS很容易穿过胎盘,对胎儿发育和长期儿童健康构成风险.
- 由于PFAS破坏了胎盘平衡,可能导致不良妊娠和儿童健康结果.
- 为了充分了解PFAS暴露对母亲和儿童福祉的复杂影响,进一步的研究是必不可少的.
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