血管内皮功能和血清蛋白质组在肥胖的人与湿体构成和平衡体构成之间的差异
Zhu Linghui1, Sun Ziwei2, Guan Yuanyuan1
1School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China.
概括
肥胖个体具有液湿度构成,表现出血管内皮功能障碍. 像ApoA2,ACE-2,IL-33和FoxP3这样的关键血清蛋白可能作为心血管疾病生物标志物.
科学领域:
- 心血管疾病研究研究
- 代谢学和蛋白质学
- 传统中国医学 宪法 宪法
背景情况:
- 肥胖是心血管疾病 (CVD) 的重要危险因素.
- 血管内皮功能障碍是心血管疾病的早期指标.
- 传统中医 (TCM) 将个人分为不同的宪法,如湿和平衡.
研究的目的:
- 评估肥胖个体的血管内皮功能.
- 为了确定潜在的血清蛋白生物标志物对肥胖人口中心血管疾病风险.
- 探索TCM构成和内皮功能障碍之间的关系.
主要方法:
- 招募了15名肥胖志愿者,按液湿度或平衡宪法分层.
- 使用EndoPATTM评估血管内皮功能,以测量反应性高血症指数 (RHI).
- 进行了血清蛋白质组分析以确定差异表达的蛋白质,并进行了相关性和ROC曲线分析.
主要成果:
- 与平衡组相比,液湿度构成肥胖组的RHI显着较低 (1.46 ± 0.30),比平衡组 (2.82 ± 0.78),表明内皮功能障碍.
- 在各组之间鉴定出66种不同表达的血清蛋白.
- 阿波利波蛋白A2 (ApoA2),血管素转化酶2 (ACE-2),介质蛋白-33 (IL-33),框P3 (FoxP3) 显著不同,与RHI相关.
结论:
- 肥胖个体具有液湿度构成,表现出血管内皮功能障碍.
- 改变ApoA2,ACE-2,IL-33和FoxP3的水平是肥胖个体中心血管疾病风险的潜在生物标志物.
- 这项研究强调了TCM体质与肥胖症中心血管健康之间的联系.
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