患者的人口统计和其他血液癌症 质细胞/状细胞新生病
Paul G Kemps1,2, Lennart Kester2, Marijn A Scheijde-Vermeulen2
1Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Histopathology
|January 12, 2024
概括
桑托格兰瘤是最常见的囊细胞性疾病,而不是朗格汉斯细胞囊细胞症. 许多患有囊性疾病的患者也会患上其他血液癌症,特别是成年人,这表明他们有共同的遗传联系.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 身体基因变异将许多囊细胞性疾病定义为血液性瘤.
- 了解人口特征和在囊性疾病中同时发生的血液癌症至关重要.
研究的目的:
- 为了研究诊断出囊性疾病的患者的人口特征.
- 在荷兰,在患有囊胞性疾病的患者中发现额外的血液癌症.
主要方法:
- 从1993年到2022年,利用了来自荷兰全国病理学数据库 (Palga) 的数据.
- 分析了4000多个注册的囊细胞疾病病例.
- 检查了人口统计数据和血液恶性瘤的同时发生情况.
主要成果:
- 桑托格拉努洛马是最常见的囊细胞性疾病,与朗格汉斯细胞囊细胞症 (LCH) 的常见假设相反.
- 朗格汉斯细胞囊细胞瘤 (LCH) 和青少年桑托格兰瘤 (JXG) 在幼儿时期出现高峰发病率,男性占比过高.
- 118名患者同时患有囊性疾病和额外的血液性恶性瘤,主要是成年人 (107/118).
- 在11/16名分析的患者中,在两种疾病中都发现了相同的遗传变化,这表明了克隆关系.
- 在B细胞急性淋巴细胞白血病与二级囊性肉瘤中发现了PAX5的改变,以及在髓状瘤中发现了N/KRAS突变.
结论:
- 基于人口的数据显示,桑托格拉努洛马是高度频繁的囊细胞性疾病.
- 这些发现支持了质细胞/状细胞新生体和其他髓状或淋巴状恶性瘤之间的克隆关系.
- 患有囊性疾病的成年患者需要对相关的血液癌症进行仔细评估.
更多相关视频
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.0K
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
29.4K
相关概念视频
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Multipotency of Hematopoietic Stem Cells
3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Hematopoiesis
5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K
Overview of Hematopoiesis
4.0K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.0K
