新型有机体培养系统用于改进纳米材料安全评估
Ahruem Baek1, Ik Hwan Kwon2, Da-Hye Lee3
1Nano-Safety Team, Safety Measurement Institute, Korea Research Institute of Standards and Science (KRISS), Daejeon 34113, Republic of Korea.
Nano letters
|January 12, 2024
概括
一个新的3D浮动有机体系统通过增强纳米粒子吸收和有机体统一性来改善纳米材料安全评估. 这种新方法克服了当前开发更安全纳米材料的系统的局限性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 纳米材料的应用引发了有关潜在毒性影响的安全问题.
- 有机器人为评估纳米材料毒性提供了高效的测定方法,但由于细胞外基质,面临着尺寸异质性和纳米粒子透率差等局限性.
- 目前的2D系统缺乏体外与体内交叉交谈.
研究的目的:
- 开发一个改进的纳米材料安全评估系统.
- 克服传统有机体培养系统的局限性.
- 增强纳米粒子内部化和有机体均性,以更好地评估毒性.
主要方法:
- 建立一个新的3D浮动有机体范式.
- 在不依赖细胞外基质的情况下培养有机体.
- 评估有机体尺寸,结构完整性和纳米粒子内部化.
主要成果:
- 在3D浮动系统中培养的有机体表现出均的尺寸和结构完整性.
- 与传统方法相比,浮式培养系统促进了更大的纳米颗粒内部化.
- 该系统解决了传统有机体和2D培养系统的局限性.
结论:
- 3D浮动器官模型是改善纳米材料安全评估的有希望的工具.
- 这种新的系统增强了纳米粒子吸收和有机体特性,促进了更安全的纳米材料的开发.
- 该方法加速了安全纳米材料领域的研究和开发.
相关概念视频
Microbial Corrosion
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
iChip
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
Microbial Biosensors
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...


