微粒相关组织因子活性与败血性传播血管内凝血患者的炎症反应相关
Shishuai Meng1, Bin Xu2, Wei Yang1
1Intensive Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
PeerJ
|January 12, 2024
概括
微粒相关组织因子活性 (TF+-MP活性) 在患有传播性血管内凝血 (DIC) 的败血症患者中升高,与炎症相关. 这表明TF+-MP活性促进了性DIC中的炎症.
科学领域:
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
- 免疫学 免疫学 免疫学
背景情况:
- 败血症经常导致扩散性血管内凝血 (DIC).
- 微粒物有助于促凝和促炎过程.
- 了解微粒相关组织因子活性 (TF+-MP活性) 在败血症引起的炎症中的作用至关重要.
研究的目的:
- 研究TF+-MP活性与败血症患者的炎症反应之间的关系.
- 为了确定TF+-MP活性是否与败血症中DIC的存在有关.
主要方法:
- 从31名患有DIC的败血症患者和31名没有DIC的败血症患者收集了血液样本.
- 使用组织因子依赖的FXa生成试验测量TF+-MP活性.
- 评估了炎症标志物,包括白细胞,中性粒细胞,前素,C-反应蛋白,互白素-1β (IL-1β) 和瘤坏死因子-α (TNF-α).
主要成果:
- 与没有DIC的患者相比,患有败血症和DIC的患者表现出更高水平的炎症标志物和TF+-MP活性.
- 在败血症患者中,TF+-MP活性与炎症反应指数和DIC得分有很强的相关性.
- 在DIC组中观察到白细胞,中性粒细胞,前素,C反应蛋白,IL-1β和TNF-α的升高.
结论:
- 在患有DIC的败血症患者中,TF+-MP活性显著升高.
- TF+-MP活性与败血性DIC的炎症反应密切相关.
- TF+-MP活性可能在性DIC期间加剧炎症中发挥关键作用.
相关概念视频
01:20Extrinsic and Intrinsic Pathways of Hemostasis
7.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.7K
01:09Coagulation
6.7K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
6.7K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
701
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
701
01:16Clot Retraction and Fibrinolysis
6.0K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.0K