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相关概念视频

Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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系统生物工程方法用于发育毒理学.

Beatriz Xavier Soares1,2, Cláudia C Miranda1,2,3, Tiago G Fernandes1,2

  • 1Department of Bioengineering and iBB - Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

Computational and structural biotechnology journal
|January 12, 2024
PubMed
概括

系统生物工程为发育毒理学提供了一个整体的方法,检查毒剂如何影响发育中的生物体. 该方法有助于识别关键的生物途径,并开发预测风险模型.

关键词:
发展性毒理学 发展性毒理学高通量选的高通量选人类多能干细胞是人类多能干细胞.数学建模的数学建模系统生物工程系统生物工程

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科学领域:

  • 发展性毒理学 发展性毒理学
  • 系统生物学 系统生物学
  • 生物工程是生物工程.

背景情况:

  • 发育性毒理学研究了外部因素对发育中的生物体的影响.
  • 传统方法可能无法完全捕捉复杂的相互作用.
  • 整合系统生物学和生物工程提供了一个新的视角.

研究的目的:

  • 探索系统生物工程在发育毒理学的应用.
  • 突出对毒性影响的整体理解的好处.
  • 展示应用到发育毒性研究的工程原理.

主要方法:

  • 审查有关毒理学系统生物工程的当前文献.
  • 分析展示发育毒性工程原理的案例研究.
  • 讨论系统生物学和生物工程概念的整合.

主要成果:

  • 系统生物工程提供了对有毒物质相互作用的整体观点.
  • 这种方法有助于识别关键的生物通路.
  • 它有助于开发发展性毒性风险的预测模型.

结论:

  • 系统生物工程对于推进发育毒理学具有高度相关性.
  • 工程原理提高了对复杂生物系统的理解.
  • 这种跨学科的方法对于未来的风险评估至关重要.