TSCRE:针对瘤特异性cis调控元素的综合数据库
Guanjie Peng1,2,3, Bingyuan Liu1,2,3, Mohan Zheng2
1Clinical Big Data Research Center, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, P.R. China.
NAR cancer
|January 12, 2024
概括
在TSCRE数据库中列出了人类癌症中失调的cis调节元件 (CREs) 和超 cis调节元件 (SCREs). 该资源有助于识别新型癌症生物标志物,并了解瘤中的基因调节.
科学领域:
- 基因组学和癌症生物学
- 非编码DNA和基因监管法规.
背景情况:
- 双调节元件 (CREs) 和双调节元件 (SCREs) 是关键的非编码DNA区域,控制基因转录和发育.
- 改变的CRE和SCRE活性与瘤基因和瘤抑制剂失调有关,影响癌症的进展.
- 需要在人类癌症中对失调的CREs和SCREs提供全面的资源.
研究的目的:
- 建立TSCRE,一个开放访问的数据库,对人类癌症的瘤特异性和细胞类型特异性CREs和SCREs进行分类.
- 为发现候选癌症生物标志物和研究基因调控机制提供一个有价值的平台.
主要方法:
- 从17种癌症类型的1366个人类患者样本中重新分析了公开可用的基因组修饰概况.
- 通过使用9个基因组标记,识别和注释失调的CREs和SCREs.
- 整合包括基因关联,表达,突变和临床数据在内的全面注释.
主要成果:
- 在TSCRE中,有1,864,941个失调的CREs和68,253个失调的SCREs.
- 超过95%的已识别的元素在公共资源中得到了验证.
- 该数据库提供详细的注释和综合途径/转录因子丰富分析.
结论:
- TSCRE为探索人类癌症中失调的CREs和SCREs提供了全面和验证的资源.
- 该平台促进了深入的功能调查和发现潜在的癌症生物标志物和治疗点.
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