通过当前的SARS-CoV-2变种BA.2.86和JN.1进行幽默性免疫逃生,2023年12月
Lara M Jeworowski1,2, Barbara Mühlemann1,3,2, Felix Walper1
1Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
概括
新的SARS-CoV-2变种JN.1和BA.2.86显示免疫逃生. 虽然中和逃脱是显而易见的,但它可能不能完全解释JN.1在全球的快速增长.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 严重急性呼吸综合征-冠状病毒-2 (SARS-CoV-2) 变种的出现和全球传播,包括BA.2.86及其后代JN.1,需要持续监测它们的免疫逃避特性.
- 了解疫苗接种和先前感染的个体对这些不断变化的变体的血清的中和能力,对于公共卫生战略至关重要.
研究的目的:
- 评估2023年9月起的血清对活体SARS-CoV-2变种的中和活性,包括JN.1,BA.2.86,EG.5和XBB.1.5.5.
- 为了确定像JN.1和BA.2.86这样的特定变种是否与其他流通的菌株相比表现出明显的免疫逃逸.
主要方法:
- 隔离活的SARS-CoV-2变种:JN.1,BA.2.86,EG.5,XBB.1.5,以及早期的菌株.
- 使用2023年9月从39名健康接种疫苗和暴露个体收集的血清进行活病毒中和试验.
- 对不同SARS-CoV-2变种中中和逃脱的比较分析.
主要成果:
- 塞拉证明了对最近的SARS-CoV-2变种的清晰中和逃脱.
- 与其他近期变种相比,在BA.2.86或JN.1变种中没有观察到特定的明显中和逃逸.
- 观察到的中和逃逸与最近的变种占主导地位相关,但可能不是JN.1上升的唯一驱动因素.
结论:
- 免疫逃生是目前流传的SARS-CoV-2变种的特征特征.
- 虽然JN.1和BA.2.86表现出中和逃逸,但它们的特异性逃逸并不明显大于其他当代变种.
- 需要进一步的研究来阐明导致JN.1变种发病率迅速增加的因素.
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