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异常的DNA修复揭示了基因组H3.3突变脑瘤中的一个漏洞

Giulia Giacomini1, Sandra Piquet1, Odile Chevallier1

  • 1Epigenetics & Cell Fate Centre, CNRS/Université Paris Cité, Paris, France.

Nucleic acids research
|January 12, 2024
PubMed
概括

患有H3.3突变的儿科高度质瘤通过非同类末端结合 (NHEJ) 呈现异常DNA修复,这种修复由PNKP介导. 向PNKP为这些侵袭性脑瘤提供了一个新的治疗策略.

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