大麻渴望预测在精神分裂症中吸烟:来自两项大麻戒断研究的二次分析
Samantha Johnstone1, Maryam Sorkhou1,2, Molly Zhang1,2
1Addictions Division and Centre for Complex Interventions (CCI), Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
The American journal of drug and alcohol abuse
|January 12, 2024
概括
重复性跨磁刺激 (rTMS) 可能有助于减少精神分裂症患者的大麻使用. 这种干预也显示出改善精神分裂症患者认知功能的潜力,为治疗提供了新的途径.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 精神分裂症通常与高比例的并发性物质使用有关,特别是大麻.
- 在精神分裂症中使用大麻可以加剧积极和消极症状,并加剧认知缺陷.
- 目前用于治疗精神分裂症大麻使用障碍的治疗方法的有效性有限.
研究的目的:
- 研究重复性横磁性刺激 (rTMS) 在减少精神分裂症患者吸食大麻的疗效.
- 评估rTMS对被诊断为精神分裂症的个体认知结果的影响.
- 探索rTMS作为一种潜在的辅助疗法,用于管理伴随性大麻使用和精神分裂症认知障碍.
主要方法:
- 进行了一项临床试验 (NCT03189810),以评估rTMS的影响.
- 参与者包括被诊断患有精神分裂症和有大麻使用史的人.
- 使用了标准化的认知评估和大麻使用频率/数量的测量.
主要成果:
- 初步发现表明,在rTMS治疗组中,大麻消费可能会减少.
- 观察到特定认知领域的改善,如记忆和执行功能.
- 目前正在进行进一步的分析,以确定这些影响的统计学意义和临床相关性.
结论:
- 重复的横性磁刺激显示为解决精神分裂症大麻使用的新型治疗策略有前途.
- 在这种患者群体中,rTMS可能会为认知增强带来好处.
- 需要进行额外的研究来证实这些发现,并优化对精神分裂症的rTMS协议.
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