印度患者中的产生生物膜的抗生素耐药细菌:综合性审查
Susmita Datta1, Soma Nag1, Dijendra Nath Roy2
1Department of Chemical Engineering, National Institute of Technology, Agartala, Tripura, India.
Current medical research and opinion
|January 12, 2024
概括
微生物生物膜由于抗生素耐药性增加而构成严重的医疗威胁. 常见的细菌如埃舍里希亚菌,链球菌和葡萄球菌在印度患者中形成这些耐药生物膜,使感染复杂化.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 微生物生物膜在医疗保健中构成越来越大的威胁,导致持续性和难以治疗的感染.
- 生物膜保护细菌免受抗生素的侵害,并提供宿主免疫反应,特别是在内置医疗设备上.
- 生物膜形成细菌的抗生素耐药性是全球主要的健康问题.
研究的目的:
- 审查印度患者中生物膜形成细菌的患病率及其抗生素耐药性的情况.
- 确定与生物膜形成和耐药性相关的常见细菌物种.
- 突出生物膜对各种感染类型的影响.
主要方法:
- 从PubMed. 的大约30份临床研究报告的文献综述.
- 对印度患者群体中生物膜形成和抗生素耐药性的研究进行分析.
- 识别流行细菌物种和相关的感染类型.
主要成果:
- 在细菌中观察到高频率的生物膜形成,如埃舍里希亚菌,链球菌,葡萄球菌和伪菌物种.
- 这些细菌对临床医生处方的常见抗生素表现出显著的耐药性.
- 在印度患者中,与生物膜相关的感染在尿道,呼吸道,牙,皮肤和植入物相关的感染中很常见.
结论:
- 生物膜形成细菌,特别是埃舍里希亚菌,链球菌,葡萄球菌和伪菌,在印度患者中很普遍.
- 这些细菌表现出多种药物耐药性,加剧了与医疗保健相关的感染.
- 随着生物膜相关感染的增加,需要有针对性的治疗策略.
更多相关视频
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
6.5K
04:26Author Spotlight: Advancing Mycobacterial Biofilm Protocols for Enhanced Bacterial Metabolism Research
Published on: July 12, 2024
860
相关概念视频
01:29Biofilms
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
01:28Gene Regulation in Microbial Communities: Quorum Sensing
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
01:27Production of Antibiotics
Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
01:25Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...