不同类型的肠道微生物群对果和胰岛素的动态反应
Pingping Yin1,2, Shanrong Yi1,2, Ting Du1,2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China. zhaiqixiao@jiangnan.edu.cn.
Food & function
|January 12, 2024
概括
细菌类/双细菌 (Ba/Bi) 的基线比率显著影响肠道微生物群对诸如果酸糖 (FOS) 和胰岛素等益生菌的反应. 更高的Ba/Bi比率表明,摄入益生菌对健康的潜在益处更大.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 肠道微生物组研究研究
背景情况:
- 果醇糖 (FOS) 和胰岛素是已知的具有健康益处的益生菌.
- 对益生菌的个体反应因宿主遗传学和肠道微生物群组成而有所不同.
- 细菌类/双杆菌 (Ba/Bi) 的比率是肠道碳水化合物利用的关键指标.
研究的目的:
- 为了研究基线Ba/Bi比对肠道微生物群和代谢功能的影响,在体外发酵FOS和胰岛素.
- 确定不同的Ba/Bi比如何影响益生菌干预措施的疗效.
- 为了确定与特定的益生菌反应相关的微生物特征.
主要方法:
- 使用高 (H) 和低 (L) Ba/Bi比率的个体的肠道微生物群在体外发酵FOS和胰岛素.
- 分析肠道微生物群的组成和多样性 (α-多样性).
- 评估代谢功能,包括短链脂肪酸 (SCFA) 生产和碳水化合物降解.
主要成果:
- 基线的Ba/Bi比对肠道微生物群的影响比预微生物类型更大.
- 与L组相比,H组显示出更大的微生物α多样性和有益细菌 (如Ruminococcus gnavus,Blautia) 的显着增加.
- 致病细菌 (例如,Escherichia Shigella) 在H组显著减少,H组也表现出增强的碳水化合物降解和脂肪酸合成.
- 回归建模将特定的微生物群与SCFA水平联系起来,FOS和胰岛素与不同的生态作用有关.
结论:
- 基线Ba/Bi比率是预测益生菌疗效的关键因素.
- 具有高Ba/Bi比的个体更有可能从FOS和胰岛素干预中受益.
- 根据Ba/Bi比率和相关微生物群概况对种群进行分层,可以优化益生菌的应用,并解释各种健康结果.
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