焦虑症治疗耐药性的定义:基于德尔菲方法的共识指南
Katharina Domschke1, Patrik D Seuling1, Miriam A Schiele1
1Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
概括
定义耐治疗焦虑症 (TR-AD) 对于临床试验至关重要. 专家们为TR-AD制定了国际标准,帮助未来的研究和治疗持续焦虑的开发.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 焦虑症是常见的和持久的,具有显著的治疗耐药性.
- 缺乏对抗治疗焦虑症 (TR-AD) 的明确定义,阻碍了临床试验.
- 对TR-AD患者需要创新的治疗干预措施.
研究的目的:
- 建立国际商定的,一致的和临床上有用的成年人TR-AD的操作标准.
- 为设计未来机理学研究和监管性临床试验提供基础.
- 为基于证据的循序渐进护理治疗算法的开发提供信息.
主要方法:
- 基于德尔菲方法的共识方法,涉及36个多学科的国际专家和利益相关者.
- 在系统审查和问卷后,对书面陈述进行了三轮匿名投票.
- 共识定义为小组成员之间≥75%的共识.
主要成果:
- 关于定义TR-AD的14项建议的协议.
- 对抗药物和/或心理治疗治疗的详细操作标准.
- 为TR-AD开发一个潜在的分期模型.
- 评估流行病学子组,并发症,术语,患者偏好和研究方向.
结论:
- 对TR-AD的确立的操作标准提供了一个系统的,一致的和实际的临床指南.
- 这些标准将有助于设计未来的研究,并为监管目的促进临床试验.
- 预计这一共识努力将促进焦虑症治疗的有效治疗方法的开发.
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