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针对针对c-MET的优化双离子抗体-药物联合体的工程疏水性和可制造性

Andreas Evers1, Simon Krah1, Deniz Demir1

  • 1Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.

mAbs
|January 12, 2024
PubMed
概括

针对c-MET的工程双类抗体显示出对抗体-药物合物 (ADC) 的改进性质. 这些优化的抗体提高了稳定性和产能,为未来的癌症治疗提供了一个有希望的平台.

关键词:
抗体工程是一种抗体工程.这是一种双相形ADC.c-MET的使用情况.疏水性是指对水的疏水性.可以制造的可制造性.

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