第二胎与第一胎双胞胎:短期和长期结果的比较
Omri Zamstein1, Tamar Wainstock2, Eyal Sheiner3
1The Obstetrics and Gynecology Division, Soroka University Medical Center, Ben-Gurion University of the Negev, POB 151, Beer-Sheva, IL, Israel. omrizam9@gmail.com.
Archives of gynecology and obstetrics
|January 12, 2024
概括
双双胞胎的出生顺序不会影响长期健康. 虽然二胎双胞胎的出生体重较低,但双胞胎双胞胎都没有.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿健康 新生儿健康
- 围产期流行病学 围产期流行病学
背景情况:
- 圣经中关于雅各和以扫的叙述强调了古代对双胞胎出生顺序的兴趣.
- 了解第一胎和第二胎双胞胎之间的潜在健康差异对于产前护理至关重要.
研究的目的:
- 为了比较第二胎和第一胎双胞胎之间的短期和长期健康结果.
- 评估出生顺序对新生儿健康指数和儿童发病率的影响.
主要方法:
- 一个基于人口的二二双胞胎分娩队列研究 (1991-2021年).
- 使用通用估计方程 (GEE) 和考克斯比例危险模型进行混调整.
- 通过卡普兰-梅尔分析比较住院率,累积发病率和出生结果.
主要成果:
- 其次出生的双胞胎出现了较高的剖腹产率和较低的出生体重,包括更小的妊娠年龄 (SGA) 和低出生体重.
- 初生双胞胎显示出更不令人放心的胎儿心率模式的趋势.
- 根据出生顺序,没有观察到死亡率或儿童发病率 (传染性,呼吸道,神经,心血管) 的显著差异.
结论:
- 双双胞胎的出生顺序与不良的新生儿健康结果无关,除了出生体重差异.
- 双胞胎出生顺序并不能预测儿童患病率的风险增加.
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