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帕金森病中冲动控制障碍的预后:一项前性受控研究

Thomas Wirth^1,2,3, Thibaut Goetsch⁴, Jean-Christophe Corvol⁵

¹Service de Neurologie, Hôpitaux Universitaires de Strasbourg, 67098, Strasbourg, France. thomas.wirth@etu.unistra.fr.

Journal of neurology

|January 12, 2024

概括

帕金森病 (PD) 中的冲动强迫性障碍 (ICD) 通常是慢性,并与更高的精神疾病负担相关. 然而,患有ICD的患者随着时间的推移显示出更好的认知预后.

科学领域:

神经科学是一个神经科学.
神经学神经学
精神病学是一个精神病学.

背景情况:

帕金森病 (PD) 中冲动强迫性障碍 (ICD) 的长期预后尚不清楚.
ICD越来越多地被认为是PD的重要非运动症状.
了解ICD的自然史对于患者管理至关重要.

研究的目的:

评估帕金森病 (PD) 中ICD的长期自然史.
评估ICD对PD运动和认知症状的影响.
检查与PD中ICD相关的治疗调整和社会后果.

主要方法:

在基线和2年后评估了患有 (BL-ICD+) 和没有 (BL-ICD-) ICD的PD患者.
在ICD评估中使用了阿尔杜安的PD行为量表 (ASBPD).
使用马蒂斯尺度测量认知能力,使用UPDRS得分测量PD症状.

主要成果:

在随访时,53.8%的基线ICD患者仍然患有ICD,而21.1%的非ICD患者患有ICD.
基线ICD患者更频繁地出现了运动症状恶化 (无动性,刚性),并考虑降低或取消多巴胺激动剂剂量.
与随访时的对照人群相比,基线ICD患者的认知衰退不那么普遍.

结论:

在PD中的ICD与增加的精神病学负担和更好的认知预后有关.
在帕金森病中,ICD似乎是一种慢性神经精神疾病.
调查结果强调需要在PD患者中制定ICD综合管理策略.

关键词:

认知认知是一种认知.多巴胺激素激动剂是多巴胺激活剂.冲动控制障碍冲动控制障碍帕金森病是帕金森氏症的一种疾病.预测预后预测预测

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