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维生素D与人类健康:孟德尔随机化研究的证据

Aiping Fang^1,2, Yue Zhao¹, Ping Yang^3,4

¹Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou, China.

European journal of epidemiology

|January 12, 2024

概括

门德尔的随机化研究表明,维生素D显著降低了多发性硬化症的风险. 证据还将维生素D与许多其他健康结果的风险和益处联系起来.

科学领域:

营养流行病学营养流行病学
遗传流行病学遗传流行病学
公共卫生公共卫生

背景情况:

维生素D对健康的作用得到了广泛的研究,但与特定结果的因果关系需要有力的证据.
门德尔随机化 (MR) 提供了一个强大的工具,可以使用遗传变异来调查因果关系.
综合当前的MR证据对于理解维生素D对各种健康状况的影响至关重要.

研究的目的:

对维生素D和健康结果的门德尔随机化研究进行系统的审查和元分析.
评估基因预测的25-氧维生素D (25(OH) D) 度与各种健康结果之间的因果关系.
评估现有MR研究在该领域的方法质量.

主要方法:

在PubMed和Embase进行全面的文献搜索,查找2022年9月1日之前对维生素D的MR研究.
包括线性MR研究,但不包括非线性MR研究,因为方法问题.
符合条件的研究的元分析,不包括重叠样本,并使用STROBE-MR检查清单进行评估.

主要成果:

133个MR出版物检查了维生素D和275个健康结果之间的因果关系.
基因上高的25OHD与多发性硬化症,骨折,心力衰竭和某些癌症的风险降低有关.
贝塞特病,格雷夫斯病,结石和基底细胞癌的风险增加.

结论:

强有力的证据支持维生素D在多发性硬化症的发展中起因作用.
研究结果表明,维生素D对几种疾病有潜在的益处,对其他疾病有潜在的风险.
在MR研究中的方法异质性强调了需要仔细解释和进一步研究的需要.

关键词:

25 基维生素 D 的含量.门德尔的随机化进行元分析分析.系统性审查系统性审查维生素D 维生素D是一种维生素.

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