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在患有重度抑郁症的年轻人中,心脏自主功能被保留

Ashley M Darling¹, Cynthia M Dominguez², Rachel J Skow^1,3

¹Department of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.

American journal of physiology. Heart and circulatory physiology

|January 12, 2024

概括

年轻成年人患重度抑郁症 (MDD) 似乎不会影响心脏自主功能,包括心率变化和巴罗反射敏感性. 抑郁症症状严重程度也显示,在这个人群中,与自主功能障碍无关.

科学领域:

心脏病学心脏病学
精神病学是一个精神病学.
自主神经科学自主神经科学

背景情况:

重度抑郁症 (MDD) 在年轻人中很普遍,与心血管疾病 (CVD) 风险增加有关.
这种关联背后的机制,特别是心脏自主功能,尚不清楚.
之前对患有MDD的年轻成年人的研究已经产生了关于心脏自主功能的不一致的发现.

研究的目的:

为了研究与健康成年人相比,患有MDD的年轻,未经药物治疗的成年人心率变化 (HRV) 和心脏巴罗反射灵敏度 (BRS).
检查患有MDD的年轻成年人的抑郁症状严重程度和心脏自主功能之间的关系.

主要方法:

在卧卧状态下持续记录心率和节拍血压.
评估HRV (RMSSD) 和心脏BRS (整体增益) 在37个没有药物治疗的MDD轻度至中度的成年人和28名健康成年人 (HA) 中.
统计分析比较HRV和BRS在不同组之间,并与症状严重程度相关联.

主要成果:

在MDD和HA的年轻成年人之间,没有发现HRV (RMSSD:79±36毫秒对63±34毫秒) 或心脏BRS (整体增益:23±7毫秒/mmHg对21±10毫秒/mmHg) 的显著差异.
在MDD组中,当前抑郁症状严重程度和HRV (R2=0.004) 或心脏BRS (R2=0.02) 之间没有观察到任何关联.
这些发现表明,在轻度至中度MDD的年轻,未服用药物的成年人中,心脏自主功能得到保护.

结论:

心脏自主功能,特别是HRV和BRS,似乎在轻度至中度MDD的年轻,未服用药物的成年人中得到保护.
患有MDD的年轻成年人心血管疾病风险增加可能不能直接归因于心脏自主功能障碍.
需要进行进一步的研究,以探索其他可能的机制,将MDD与心血管风险联系起来.

关键词:

自主神经系统自主神经系统心脏巴罗反射灵敏度心脏巴罗反射灵敏度抑郁抑郁症抑郁症抑郁症是一种心率变化的心率变化.

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