托芬摄入量和胰腺癌:来自病例控制研究的发现
Hung N Luu1,2, Yen Thi-Hai Pham1,2, Jian-Min Yuan1,2
1University of Pittsburgh Medical Center Hillman Cancer Center.
概括
较高的食托摄入量与胰腺癌的风险降低有关. 这项在越南的研究表明,增加托消费可能是胰腺癌的预防性饮食策略.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 胰腺癌是全球重要的健康问题,死亡率高.
- 一种必不可少的氨基酸 - - 氨酸,对蛋白质合成和细胞功能至关重要.
- 以前的动物研究表明,托在增强癌症治疗反应中的作用.
研究的目的:
- 调查饮食托摄入量与胰腺癌风险之间的关联.
- 评估托芬作为预防胰腺癌的饮食因素的潜力.
主要方法:
- 在越南进行了一项病例控制研究,涉及3759例癌症病例和2995例对照.
- 使用食物频率调查问卷评估了托芬摄入量.
- 使用无条件逻辑回归分析来确定赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 观察到托芬摄入量与胰腺癌风险之间存在显著的反向剂量依赖关系 (Ptrend = 0.02).
- 摄入托芬较多的个体显示胰腺癌的几率降低 (连续摄入OR=0.51;OR=0.27-0.34为三位数2和3与三位数1).
- 保护性关联在BMI<23 kg/m2的个体和常饮酒者中更为明显.
结论:
- 饮食中托摄入量较高与越南人口胰腺癌发病率较低显著相关.
- 饮食修改,特别是增加托消费,可能是胰腺癌初级预防的可行策略.
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