通过风险分析和名谱,可以预测双J支架层吗? :一个回顾性病例控制研究
Zicheng Liu1, Minbo Yan, Yaser Naji
1Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
Medicine
|January 12, 2024
概括
这项研究确定了双J支架结的关键风险因素,包括停留时间,尿液pH,血糖和胆固醇. 一个经过验证的nomogram现在可以预测在患有上泌尿道结石的患者内的风险.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医疗信息学 医疗信息学
背景情况:
- 双J支架结是尿路手术后的一种并发症.
- 需要用于支架层的预测工具来改善患者的治疗结果.
- 需要进一步阐明双J支架层的危险因素.
研究的目的:
- 为了确定双 J 支架层的独立风险因素.
- 开发和验证双J支架层的预测性名录.
- 帮助临床医生评估和管理患有支架层风险的患者.
主要方法:
- 追溯分析248名接受内镜性石和双J支架的患者.
- 开发队列 (173名患者) 用多变量逻辑回归来识别风险因素.
- 验证队列 (75名患者) 来评估名图表的性能 (AUC,校准).
主要成果:
- 确定了双J支架结的重大风险因素:内置时间 (OR 1.051),尿液pH (OR 2.198),禁食血糖 (OR 1.590) 和总胆固醇 (OR 2.676).
- 开发了一种具有良好的预测性能 (AUC 0.870在开发中,0.862在验证中).
- 诺米图表表现出良好的校准,表明了一个非常适合的预测模型.
结论:
- 停留时间,尿液pH值,禁食血糖和总胆固醇是双J支架结的重要预测因素.
- 开发的诺米图是用于预测双J支架结风险的有效和可访问的工具.
- 这种名图可以帮助泌尿科医生对患有双J支架的患者进行风险分层和临床决策.
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