显著的氨基酸配置描述了患有或有2型糖尿病风险的年轻人
Fida Bacha1,2,3, Heba El-Ayash1,2,3, Mahmoud Mohamad1,3
1U.S. Department of Agriculture, Agricultural Research Service, Children's Nutrition Research Center, Houston, TX.
Diabetes
|January 12, 2024
概括
一种特定的氨基酸 (AA) 签名可以预测青少年的2型糖尿病风险. 较低的甘氨酸和谷氨酸与谷氨酸的比率,以及更高的分支链氨基酸 (BCAA),芳香氨基酸 (AAA) 和素,表明β细胞衰竭的风险更高.
科学领域:
- 代谢学 代谢学 代谢学
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 分链氨基酸 (BCAA) 和芳香氨基酸 (AAA) 与成人2型糖尿病 (T2D) 风险有关,但青少年的研究结果不一致.
- 识别患有T2D和随后的β细胞衰竭风险的年轻人对于早期干预至关重要.
研究的目的:
- 定义一种氨基酸 (AA) 代谢特征,以识别易患β细胞衰竭和T2D发病的青少年.
- 研究青少年的AA度,胰岛素敏感性和β细胞功能之间的关系.
主要方法:
- 对127名青少年 (15.5岁) 的氨基酸有针对性的代谢分析,体重和血糖状况各不相同.
- 评估胰岛素敏感性 (IS) 和β细胞功能 (每无脂肪质量的排放指数,DIFFM) 使用高胰岛素血糖-欧糖和高糖.
- 在禁食和紧紧的条件下,通过质谱测量量AA度的量化.
主要成果:
- 与正常体重的个体相比,患有肥胖和失糖症的青少年表现出较低的甘氨酸 (Gly) 度和谷氨酸 (Gln) 与谷氨酸 (Glu) 的比率.
- 在患有肥胖和失糖症的青少年中观察到较高的BCAA,氨酸和氨酸度 (Lys).
- Gly和Gln-to-Glu比率与IS和DIFFM正相关,而BCAA,AAA和Lys则显示出反向关系.
结论:
- 一个独特的代谢特征,以低的Gly和Gln-to-Glu比率为特征,以及高的BCAA,AAA和Lys,可以作为生物标志物来识别面临β细胞衰竭风险的年轻人.
- 这种特征可能有助于在青少年群体中早期对2型糖尿病风险分层.
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