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素基因相关的受体对抗性降低了老鼠偏头痛模型中的运动病指标

Shafaqat M Rahman¹, Anne E Luebke^1,2

¹University of Rochester, Department of Biomedical Engineering, Rochester, NY, USA.

Cephalalgia : an international journal of headache

|January 12, 2024

概括

卡尔西托尼基因相关 (CGRP) 和酸尼托普鲁塞德增加了小鼠的运动恶性. 虽然CGRP受体对抗剂,但不是三类药物,但它们有效地减少了运动诱导的恶心.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

偏头痛和前置偏头痛涉及增加的运动敏感性,导致恶心和运动恶心.
静脉偏头痛影响大约3%的美国成年人,女性不成比例地受到影响.
目前的偏头痛治疗方法,如三药,对和运动诱导的恶心无效.

研究的目的:

调查像CGRP和SNP这样的偏头痛触发剂是否会增加小鼠的运动恶心.
为了确定偏头痛抑制剂是否可以减轻CGRP或SNP诱导的运动恶心.
评估特定偏头痛治疗药物对运动诱导的恶心的疗效.

主要方法:

小鼠 (C57BL/6J) 接受了CGRP或SNP的腹腔内注射.
使用运动病指数 (MSI) 评分和运动诱导温度调节来评估运动病.
评估了 olcegepant,sumatriptan 和 rizatriptan 作为偏头痛抑制剂的疗效.

主要成果:

由于CGRP的胃肠道影响,MSI评分是不可靠的.
尾部血管扩张,恶心的替代品,为这两种触发因素提供了可靠的数据.
只有olcegepant治疗成功地逆转了诱导的尾巴血管扩张.

结论:

临床前数据表明,CGRP受体对抗剂对治疗偏头痛相关的运动诱导性恶心是有效的.
在这种偏头痛模型中,基于三的治疗方法在运动诱导的恶心方面表现得无效.
这些发现支持探索 vestibular偏头痛症状的小分子CGRP受体对抗剂.

关键词:

这是CGRP的CGRP.胃的痛苦胃的痛苦偏头痛偏头痛偏头痛偏头痛运动性 motion-sickness 运动性 motion-sickness 运动性 motion-sickness 运动性 motion-sickness 运动性 motion-sickness 运动性疾病这里是鼠标鼠标鼠标鼠标鼠标鼠标.恶心恶心恶心一个古老的石头.里扎特里普坦 (Rizatriptan) 是一种苏马特里普坦的使用方法这是前置体前置体.

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