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沙门氏菌外膜囊泡对肠道微生物群和肠道屏障功能的影响

Meiying Luo¹, Suqian Li¹, Yang Yang¹

¹School of Life Science and Engineering, Foshan University, Foshan, China.

Foodborne pathogens and disease

|January 12, 2024

概括

沙门氏体外膜囊泡 (SeOMVs) 破坏肠道微生物群和屏障功能. SeOMVs对动物生长和肠道健康产生负面影响,这表明它在S. enterica的病原发生中发挥了作用.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

沙门氏菌 (Salmonella enterica) 是导致食物传播疾病的主要原因之一.
外膜囊泡 (OMVs) 是参与病变发生的细菌组成部分.
S. enterica OMVs (SeOMVs) 在疾病发病中的作用尚不清楚.

研究的目的:

研究SeOMVs对肠道微生物群的影响.
评估SeOMVs对肠道屏障功能的影响.
确定SeOMVs在S. enterica引起的疾病中的作用.

主要方法:

在体外便和IPEC-J2细胞培养.
在体内小鼠模型中给予SeOMVs.
分析微生物群的组成,短链脂肪酸 (SCFA),动物生长,血清细胞因子和阴茎组织学.

主要成果:

在实验室中,SeOMVs改变了便微生物群的多样性,并减少了SCFA的产生.
SeOMVs损害了小鼠的生长,降低了IL-10水平,并在体内改变了肠道细菌的丰富性.
SeOMVs造成了大肠粘膜损伤,并表明在炎症反应中发挥了作用.

结论:

通过破坏肠道微生物群和屏障功能,SeOMVs有助于S. enterica的致病性.
降低SCFA产生细菌的调节是SeOMV诱导炎症的潜在机制.
SeOMVs在激活肠道炎症反应方面发挥着重要作用.

关键词:

沙门氏菌是一种沙门氏菌.屏障的功能是屏障的功能.我们的肠道微生物群.在外膜囊泡中,外膜囊泡猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪

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