母亲抑郁症与小学龄女儿下尿道症状之间的关联:出生队列研究
Shayna D Cunningham1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19, Sarah Lindberg1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19, Carol Joinson1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
1Shayna D. Cunningham, PhD, Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington.
概括
怀孕期间和分娩后的母亲抑郁症与女儿下尿道症状 (LUTS) 的风险增加有关. 对母亲心理健康的早期干预可能有助于预防儿童LUT.
科学领域:
- 生殖健康 生殖健康
- 儿童发展 儿童发展
- 心理健康 心理健康
背景情况:
- 母亲抑郁症会影响母亲和孩子的幸福感.
- 母亲抑郁症和后代下游泌尿道症状 (LUTS) 之间的联系需要进一步调查.
研究的目的:
- 为了检查产前和产后母亲抑郁症和小学龄女儿的LUTS之间的联系.
主要方法:
- 一个观察性队列研究的7148母女双从父母和孩子的艾文纵向研究.
- 在怀孕期间和产后评估了母亲的抑郁症状.
- 在6岁,7岁和9岁时使用问卷评估了童年LUTS (紧急性,夜尿,白天/夜间湿).
- 多变量逻辑回归分析了母亲抑郁症和女儿LUTS之间的关联.
主要成果:
- 患有产前和产后抑郁症的母亲的女儿出现LUTS的几率明显更高,包括尿急 (aOR 1.99-2.50) 和夜尿 (aOR 1.67-1.97).
- 在6岁和7岁观察到日间 (aOR1.81-1.99) 和夜间 (aOR1.63-1.95) 湿的几率增加.
- 对于仅限于产前或产后期的抑郁症,相关性不那么一致.
结论:
- 产前和产后母亲的抑郁症暴露与女儿患LUTS的可能性更高有关.
- 这一发现为儿童LUTS预防提供了机会.
- 预防策略应考虑生物和环境途径,将孕产妇抑郁症与童年抑郁症联系起来.
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