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相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

8.3K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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What is Population Genetics?01:25

What is Population Genetics?

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A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
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Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Gene Conversion02:08

Gene Conversion

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
9.8K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.0K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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What is Genetic Engineering?00:49

What is Genetic Engineering?

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Overview
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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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佩加:一种保护隐私的遗传算法,用于组合优化.

Bowen Zhao, Wei-Neng Chen, Feng-Feng Wei

    IEEE transactions on cybernetics
    |January 12, 2024
    PubMed
    概括
    此摘要是机器生成的。

    本研究介绍了基于云计算的进化计算作为服务 (ECaaS) 的隐私保护遗传算法 (PEGA). PEGA使用户能够安全有效地解决复杂的组合优化问题,而不会泄露敏感数据.

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    Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
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    科学领域:

    • 计算机科学 计算机科学
    • 人工智能的人工智能
    • 密码学 密码学 密码学 密码学

    背景情况:

    • 对于缺乏专业知识或资源的用户来说,组合优化问题 (COP) 是一个挑战.
    • 将这些计算外包到云端引发了严重的隐私问题.
    • 现有的解决方案往往需要专业知识或损害数据保密性.

    研究的目的:

    • 提出一种新的计算范式,即进化计算作为服务 (ECaaS).
    • 为COPs引入一个保护隐私的遗传算法 (PEGA).
    • 为那些资源或专业知识有限的用户提供安全有效的基于云的优化.

    主要方法:

    • 为PEGA开发了一个双服务器架构.
    • 在加密数据上利用加密密码学和安全计算协议为GA运营商.
    • 实施和评估PEGA在旅行销售员问题 (TSP) 和0/1Knapsack问题 (KP) 上.

    主要成果:

    • PEGA有效地使用户能够在没有领域专业知识或足够的资源的情况下解决COP.
    • 该系统通过防止优化问题细节的泄露,成功地保护了用户的隐私.
    • 在接近最佳解决方案方面,PEGA表现出与传统遗传算法相当的性能.

    结论:

    • 佩加为保护隐私的基于云的优化提供了一个可行的解决方案.
    • 在ECaaS范式促进访问先进的计算能力,同时确保数据保密.
    • 实验结果验证了PEGA对TSP和KP的有效性和安全性.