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在接受teprotumumab治疗的甲状腺眼病患者中出现月经不规律和缺血

Anna K Terrarosa¹, Lauren N DeMaria^1,2, Victoria S North³

¹Department of Ophthalmology, New York University, New York City, New York, U.S.A.

Ophthalmic plastic and reconstructive surgery

|January 12, 2024

概括

大多数 (75%) 用teprotumumab治疗甲状腺眼部疾病的患者经历了月经不规则或缺血. 这些月经变化通常在治疗后得到解决,尽管一些患者有持续的问题.

科学领域:

内分泌学在内分泌学.
眼科医生眼科眼科

背景情况:

甲状腺眼病 (TED) 是一种自身免疫性疾病,影响眼睛周围的组织.
德图穆马布是一种新的生物治疗活性TED的方法.

研究的目的:

为了评估月经不规则的发生率和特征,包括 amenorrhea,在接受teprotumumab治疗的活跃TED患者.

主要方法:

在2020-2022年期间接受了8次teprotumumab注射的活跃TED的女性患者的回顾性审查.
在治疗期间和治疗后评估患者报告的月经变化 (不规则性,缺血症).
使用两个样本t测试来比较群体的统计分析.

主要成果:

在包括的12名患者中,75%的患者在接受teprotumumab治疗期间报告了月经变化.
大多数患者的月经不规则在治疗后消失;25%的患者经历了持续的变化.
一名患者在治疗完成后报告了持续的缺血,另一个患者在治疗完成后报告了缺血.

结论:

在患有甲状腺眼病的患者中,teprotumumab治疗与高比例的临时月经异常有关.
大多数月经不规则是暂时的,在停止治疗后会消失.

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