Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Other Nuclides: 31P, 19F, 15N NMR01:16

Other Nuclides: 31P, 19F, 15N NMR

385
Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...
385

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Heterocyclic Surgery for Isotopic Labeling.

Synlett : accounts and rapid communications in synthetic organic chemistry·2026
Same author

Enantioselective Total Synthesis of Two Aromatized Halicyclamines.

Journal of the American Chemical Society·2026
Same author

Azine Dearomatization in Natural Product Total Synthesis.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Enantioselective total synthesis of (+)-cylindricine B.

Chemical science·2024
Same author

Dearomative Access to (-)-Thebaine and Derivatives.

Organic letters·2023
Same author

Six-Step Synthesis of (±)-Lysergic Acid.

The Journal of organic chemistry·2023
Same journal

Decoding Galectin-Glycan Recognition with <sup>19</sup>F-Tagged Lectins: from Simple Glycans to the Cellular Glycocalyx.

Journal of the American Chemical Society·2026
Same journal

Open- and Closed-Shell Roles of Sensitizer and Annihilator in Pseudo-Single Component Mixtures for Upconversion.

Journal of the American Chemical Society·2026
Same journal

Pressure-Induced Superconductivity at 15 K in van-der-Waals Ferroelectric CuInP<sub>2</sub>S<sub>6</sub>.

Journal of the American Chemical Society·2026
Same journal

Carbene Analogues of Group 15: Reduction of s-Hydrindacene-Based Chloropnictogenium Ions To Access an Antimony Hydride Monocation and a Trinuclear Bismuth Dication.

Journal of the American Chemical Society·2026
Same journal

Chiral-Ligand-Modulated Nickel-Catalyzed Stereoselective Radical Migratory C2-Arylation of Carbohydrates.

Journal of the American Chemical Society·2026
Same journal

Coordination-Constraint-Driven Enhanced Chirality Induction in Perovskite Quantum Dot Solids.

Journal of the American Chemical Society·2026
查看所有相关文章

相关实验视频

Updated: Jul 5, 2025

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
07:23

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group

Published on: October 10, 2016

8.3K

15NRORC:一个亚标签协议

Zachary A Tolchin1, Joel M Smith1

  • 1Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, United States.

Journal of the American Chemical Society
|January 12, 2024
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种合成-15 (15N) 标记的新方法. 这种技术使各种异环化合物和药物的有效同位素标记成为可能.

更多相关视频

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
09:08

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Published on: December 20, 2024

1.4K
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

7.4K

相关实验视频

Last Updated: Jul 5, 2025

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
07:23

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group

Published on: October 10, 2016

8.3K
Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
09:08

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Published on: December 20, 2024

1.4K
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

7.4K

科学领域:

  • 有机化学
  • 同位素合成
  • 医学化学

背景情况:

  • 标有-15 (15N) 的化合物对于机理学研究和药物开发至关重要.
  • 现有的合成N标记异环的方法在范围或效率上可能是有限的.

研究的目的:

  • 开发一种实用且广泛适用的合成N-标记的氨酸方法.
  • 证明这种方法在制造标签制药时的有用性.

主要方法:

  • 使用电子缺陷激活亚异环.
  • 通过ANRORC机制将原子替换为N标记的试剂.
  • 适用于减少的异环原体的芳香合成.

主要成果:

  • 实现了高同位素丰富的N标记的氨酸.
  • 证明了该方法可用于广泛的亚基质.
  • 成功进行了N-solifenacin的形式合成.

结论:

  • 描述的方法提供了一种简单而有效的途径,以15N-标记的亚.
  • 这种方法对于合成标记药物和探索异环化学是有价值的.
  • 这种方法有助于减少含的异构循环.