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一种基于氨酸的纳米凝系统,用于对青的氧化还原和pH双响应输送

Huong Nguyen Thi¹, Son Nguyen Ngoc¹, Thanh Vu Minh¹

¹Institute of Chemistry and Materials, Academy of Military Science and Technology (Vietnam), 17 Hoang Sam, Cau Giay, Hanoi 100000, Vietnam.

Biomedical materials (Bristol, England)

|January 12, 2024

概括

这项研究开发了一种新的双响应抗癌系统,使用肝素输送西斯 (CPT). 该CPT@Hep-P407系统通过响应氧化还原和pH刺激,显示了针对癌症治疗的前景.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
癌症治疗癌症治疗

背景情况:

氨酸是一种新型抗癌药物,有可能用于组合疗法.
多刺激响应系统可以提高药物输送和杀死癌细胞的效率.
开发有针对性的药物输送系统对于改善癌症治疗结果至关重要.

研究的目的:

设计一种基于氨酸的可氧化还原和pH双响应抗癌系统,用于西斯 (CPT) 治疗.
创建一个系统,提高CPT的疗效和减少副作用.
开发一种用于向癌症治疗的新型药物输送平台.

主要方法:

氨酸通过二硫化物桥梁与Poloxamer 407交叉连接,形成Hep-P407.
西斯 (CPT) 被封装在Hep-P407中,形成了CPT@Hep-P407系统.
鉴定包括1H-NMR,泽塔潜力,DLS,FTIR,体外释放和Resazurin测定.

主要成果:

已经成功合成和表征了Hep-P407系统.
CPT@Hep-P407对氧化还原和pH刺激表现出双响应的行为.
在体外研究证实了该系统的细胞毒性和响应能力.

结论:

该CPT@Hep-P407系统是一个有前途的氧化还原/pH响应抗癌平台.
基于氨酸的药物输送系统为增强癌症治疗提供了潜在的潜力.
这种双响应系统可以改善针对癌症治疗的西斯普拉丁的向输送.

关键词:

系统交付系统的交付系统.双响应式双响应式肝素是一种肝素.对于pH值敏感的波罗克萨默斯 407 的 407 号氧化还原敏感的敏感性

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