卵巢癌的生殖线和体检:一个SGO临床实践声明
G M Gressel1, M K Frey2, B Norquist3
1Corewell Health Cancer Center, Division of Gynecologic Oncology, Michigan State University- College of Human Medicine, United States.
Gynecologic oncology
|January 12, 2024
概括
对卵巢癌患者来说,生殖系和体基因检测至关重要,有助于治疗选择和预后. 尽管有建议,但只有不到一半的患者接受了这一至关重要的测试.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 癌症研究 癌症研究
背景情况:
- 生殖线和体质遗传检测是卵巢癌护理的组成部分.
- 识别致病变体和同源重组缺陷有助于预测治疗反应,预后和适用于PARP抑制剂等向疗法的资格.
- 生殖系病原体变异也可以促进风险家庭成员的级联遗传测试.
研究的目的:
- 为了提供一个概述的胚胎和体质遗传检测对上皮卵巢癌的概述.
- 讨论可用的测试方式和护理提供选项.
- 突出普遍基因检测临床建议与当前患者接受率之间的差距.
主要方法:
- 审查当前的文献和临床指南.
- 综合有关遗传检测方式的信息.
- 来自妇科瘤学会 (SGO) 临床实践委员会的专家共识.
主要成果:
- 基因检测可以识别影响治疗反应和预后的变异.
- 聚 (ADP-ribose) 聚合酶 (PARP) 抑制剂是基因测试提供的关键向疗法.
- 尽管有建议,目前只有大约三分之一的卵巢癌患者完成了生殖系或体质遗传测试.
结论:
- 生殖系和体质遗传检测对于个性化卵巢癌管理至关重要.
- 在卵巢癌患者中,遗传检测的利用率显著不足.
- 该SGO临床实践委员会旨在指导对上皮卵巢癌的测试和护理.
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