对精神分裂症和双相情感障碍的负面性和多基因风险得分不匹配
Atle Bråthen Pentz1, Kevin Sean O'Connel1, Oda van Jole2
1NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway.
精神分裂症和双相情感障碍的遗传风险得分与听觉记忆痕迹有关,但与精神障碍中的听觉不匹配消极性无关. 这些发现表明,在这些条件下,基因与预测编码机制有联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学是一种遗传学.
背景情况:
- 听觉不匹配负面性 (MMN) 是精神病障碍的一个潜在的内分类型.
- 在这些条件下,MMN损伤的遗传基础需要进一步调查.
研究的目的:
- 调查听觉MMN和精神分裂谱系障碍 (SSD) 和双极性障碍 (BD) 的多基因风险评分 (PRS) 之间的关联.
- 探索PRS和MMN子组件之间的关系,特别是重复阳性 (RP) 和偏差阴性 (DN),在患有精神疾病的个体和健康对照中.
主要方法:
- 一组患有精神疾病的个人 (n=102) 和健康的对照 (n=397) 接受了漫游MMN听觉范式.
- 测量了MMN,RP和DN,以及从全基因组关联研究中得出的SCZ和BD PRS.
- 线性回归评估了MMN,RP,DN和PRS之间的关系.
主要成果:
- 在SCZ或BD PRS与两组中大平均MMN之间没有发现显著的关联.
- 在精神疾病组中,SCZ和BD PRS与RP负相关 (分别为p=0.005和p=0.034).
- 在DN和PRS之间没有观察到任何显著的关联.
结论:
- 对SCZ和BD的遗传变异可能会影响MMN的子组件,与精神疾病的预测编码有关.
- 需要进行更大规模的研究来验证这些发现,并充分了解导致MMN损伤的遗传因素.
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