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在自闭症谱系障碍和智力障碍儿童和青少年之间,血清脑源性神经营养因子度不同

Tingkai Cui¹, Zhao Liu¹, Zhi Li¹

¹Department of Maternal, Child and Adolescent Health, School of Public Health, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin, China.

Journal of psychiatric research

|January 12, 2024

概括

成熟的大脑衍生神经营养因子 (mBDNF) 和其前体proBDNF的血清水平在自闭症谱系障碍 (ASD) 和智力障碍 (ID) 之间有所不同. 这些神经营养素显示出作为区分ASD和ID的生物标志物的潜力.

科学领域:

神经科学是一个神经科学.
生物标志物生物标志物
发展障碍发展障碍发展障碍

背景情况:

成熟的大脑衍生神经营养因子 (mBDNF) 和proBDNF与自闭症谱系障碍 (ASD) 有关.
在ASD和智力障碍 (ID) 之间,mBDNF和proBDNF的比较水平尚未确立.
了解这些差异可能有助于差异诊断.

研究的目的:

为了比较mBDNF和proBDNF的血清度.
为了评估mBDNF/proBDNF比率在与ASD和ID的个体.
评估这些生物标志物的诊断潜力.

主要方法:

在中国天津招募了患有自闭症或智障的儿童和青少年 (4-22岁).
测量了血清中的mBDNF和proBDNF水平.
管理的智力尺度 (WPPSI,WISC) 和自闭症评估 (CARS).

主要成果:

血清mBDNF和mBDNF/proBDNF的比率在ASD组明显高于ID组 (P=0.035,P<0.001).
血清proBDNF在ASD组显著低于在ID组 (P<0.001).
在对年龄和智商进行调整后,CARS得分与mBDNF和m/p比率呈正相关,与proBDNF呈负相关. 曲线下的面积 (AUC) 值在0.741到0.854.4之间.

结论:

在ASD和ID组之间存在血清mbbDNF,proBDNF和它们的比率的显著差异.
这些神经营养素标记物显示出对ASD和ID的个体进行分类的潜力.
这些发现表明mBDNF和proBDNF可以作为有价值的生物标志物来区分这些神经发育状况.

关键词:

自闭症自闭症自闭症大脑衍生的神经营养因子智力障碍智力障碍是一种智力障碍.血清的血清是什么意思

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