在糖尿病病患者中,arctigenin和puerarin之间具有附加性保护作用
Xueling Li1, Jue Wang1, Jiayi Yan1
1Department of Nephrology A, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|January 12, 2024
概括
在糖尿病病 (DKD) 模型中,阿尔基基宁和皮亚林在保护脏方面表现出协同作用. 这些传统中医药化合物通过抑制炎症NF-κB通路来减少白蛋白尿.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 糖尿病病 (DKD) 管理受益于组合疗法.
- 传统中国医学 (TCM) 经常使用协同作用的多草药方法.
- 原蛋白 (ATG) 和原蛋白以前在DKD模型中显示出个别的保护作用.
研究的目的:
- 在糖尿病小鼠中研究阿尔基基宁 (ATG) 和皮亚林的附加性保护作用.
- 阐明它们在DKD中的综合治疗效果的潜在分子机制.
主要方法:
- 向dB/dB小鼠 (一个DKD模型) 给药ATG和puerarin.
- 评估白蛋白尿的水平.
- 对NF-κB p65酸化和乙化的分析.
- 用RNA测序来识别激活的途径.
主要成果:
- ATG和puerarin在减少白蛋白尿症方面表现出协同作用.
- 通过PP2A激活,ATG减少了NF-κB p65酸化.
- 普埃拉林通过Sirt1激活减少了NF-κB p65乙化.
- 通过对每个化合物的RNA测序确定了不同的途径.
结论:
- 在DKD中,ATG和puerarin对NF-κB炎症途径表现出添加性抑制作用.
- ATG和puerarin的组合代表了DKD潜在的新疗法策略.
- 每种化合物激活的不同分子通路有助于它们的附加效应.
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