在不同临床支持模式中,多方法调查血诱导的血液损伤
Yuan Li1, Xinyu Liu, Anqiang Sun
1From the Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
|January 12, 2024
概括
不同的血模式会影响血红相容性. 静脉动脉ECMO模式对出血,血栓形成和血液溶解的风险最高,而心力衰竭模式是最安全的.
科学领域:
- 生物医学工程 生物医学工程
- 心血管科学 心血管科学
- 血液动力学 血液动力学
背景情况:
- 身体外血对于循环支持至关重要.
- 了解不同操作模式的血液相容性对于患者安全至关重要.
研究的目的:
- 为了评估血 (CentriMag) 在三个临床模式中的血相容性:心力衰竭 (HF),静脉-静脉 (V-V) 外体膜氧化 (ECMO) 和静脉-动脉 (V-A) ECMO.
- 评估非生理学流动模式对血液成分的影响以及出血,血栓和血液溶解的风险.
主要方法:
- 利用计算流体动力学 (CFD) 来建模液压性能.
- 采用合的血液溶解,出血和血栓形成模型来预测血红相容性.
- 分析了血小板和·维勒布兰德因子 (vWF) 功能的变化.
主要成果:
- 静脉动脉ECMO模式表现出最高的流量损失和剪切应力,导致出血,血栓形成和血液溶解的风险增加.
- 心力衰竭模式显示风险最低,其中V-V ECMO是中等风险.
- 非生理学流动模式显著改变了细胞和蛋白质功能,与增加的血液损伤和并发症相关.
结论:
- 外体血的运行模式极大地影响了血液兼容性和并发症风险.
- 与V-V ECMO和HF模式相比,静脉动脉ECMO具有更高的风险概况.
- 尽量减少非生理流动模式对于减少机械循环支持期间的血液损伤至关重要.
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