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功能组对修改后的ZIF-90对光细菌的毒性产生影响

Dan Wang¹, Linming Bai¹, Wenlong Wang¹

¹Xi'an Key Laboratory of Solid Waste Recycling and Resource Recovery, Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

|January 12, 2024

概括

热性伊米达酸框架 (ZIF) 的表面功能化可以增加其毒性. 修改后的ZIF-90纳米颗粒,特别是ZIF-90-NH2,具有比原始ZIF-90更高的毒性,影响了生物医学应用.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

由于其属性,氧化伊米达酸框架 (ZIF) 显示出生物医学用途的前景.
在ZIF广泛用于生物医学应用之前,需要进行全面的安全评估.

研究的目的:

调查表面功能化对ZIF-90.0毒性的影响.
为了合成和评估ZIF-90修改了各种功能组.

主要方法:

合成ZIF-90功能化与氧基,碳基,氨基和硫基组.
使用光细菌 T3.3进行毒性评估.
分析ZIF-90-NH2的稳定性和潜在的毒性机制.

主要成果:

ZIF-90系列显示出度依赖的毒性.
功能化的ZIF-90变种比原始的ZIF-90更有毒.
ZIF-90-NH2表现出最高的毒性 (IC50 = 23.06 mg/L),与伊米达-联刚释放和正电荷相关.

结论:

表面功能化显著影响ZIF毒性.
伊米达-灵干释放和正表面电荷有助于ZIF-90-NH2的毒性.
细胞膜损伤,氧化应激和发光障碍是关键的毒性机制.

关键词:

生物发光是一种生物发光.纳米材料是一种纳米材料.安全的安全的安全的安全的安全.有毒性机制有毒性机制的 ZIF-90-90 的情况.

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