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Updated: Jul 5, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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在CD3ε上敲击的小型CAR扩展了TCR功能,在内源TCR信号级联的控制下具有CAR特异性

Katrin Manske1, Lisa Dreßler1, Simon P Fräßle1

  • 1Juno Therapeutics GmbH, A Bristol-Myers Squibb Company, Grillparzerstr. 10, Munich 81675, Germany.

Journal of immunological methods
|January 12, 2024
PubMed
概括

研究人员通过最大限度地降低CAR有效载荷大小,开发了一种新的仿真抗原受体 (CAR) T细胞疗法. 这种方法增强了CAR T细胞的活性,并保留了天然T细胞受体 (TCR) 功能,以改善癌症治疗.

关键词:
细胞工程是细胞工程.免疫学 免疫学 免疫学非病毒基因传递非病毒基因传递T细胞制造 制造 制造通过T细胞治疗治疗.

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