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在妇女健康倡议中的饮食质量和表观遗传衰老

Lindsay M Reynolds¹, Denise K Houston², Meghan B Skiba³

¹Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Journal of the Academy of Nutrition and Dietetics

|January 12, 2024

概括

更高的饮食质量与绝经后妇女的生物衰老速度减缓有关. 改善的饮食分数与减少的表观遗传衰老相关,特别是DunedinPACE,这表明饮食影响衰老生物学.

科学领域:

老年学和营养科学研究
表观遗传学和分子生物学

背景情况:

饮食质量与降低慢性疾病风险和死亡率有关.
饮食质量与生物衰老,特别是表观遗传衰老之间的关系尚不清楚.

研究的目的:

调查饮食质量与表观遗传衰老措施之间的关联.
为了确定是否坚持健康的饮食模式影响生物衰老标志物.

主要方法:

对4500名绝经后妇女 (50-79岁) 的横截面分析.
评估饮食质量,使用来自食物频率问卷的三个分数 (健康饮食指数,DASH,地中海替代) 来评估饮食质量.
使用DNA甲基化数据测量了五种表观遗传衰老标志物 (例如,AgeAccelGrim,DunedinPACE).

主要成果:

这三种饮食质量得分都与表观遗传衰老指标AgeAccelPheno,AgeAccelGrim和DunedinPACE相反相关.
较高的饮食质量评分显示与DunedinPACE有显著的反向关联,表明生物衰老速度较慢.
饮食质量得分增加1个SD相当于所有评估的饮食模式中的DunedinPACEz-score显著下降.

结论:

饮食质量与基因甲基化基因对绝经后妇女生物衰老的测量相反相关.
饮食模式与表观遗传衰老有显著的相关性,而DunedinPACE对饮食质量特别敏感.
研究结果表明,改善饮食质量可能是影响生物衰老过程的策略.

关键词:

衰老的衰老衰老的衰老通过DNA甲基化.饮食质量饮食质量女人女人女人女人女人表观遗传衰老年龄化

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