一本小说描述了多种耐药性Pseudocitrobacter sp. 的特征. 从被殖民的患者中分离出来,同时被录取到高等教学医院
S A Kelly1, N H O'Connell2, T P Thompson1
1School of Pharmacy, Queen's University Belfast, Belfast, UK.
The Journal of hospital infection
|January 12, 2024
概括
在一名患者身上发现了一种新型细菌物种Pseudocitrobacter limerickensis,该细菌物种表现出显著的抗微生物耐药性基因. 这一发现凸显了它与相关的亲属的潜在不同的进化.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 进化生物学 进化生物学
背景情况:
- 鼻腔感染通常涉及已知的病原体.
- 这项研究详细介绍了一种新型细菌物种的隔离和特征,该细菌物种来自一个被选为carbapenemases的患者.
研究的目的:
- 从临床样本中分离出来的新型细菌物种的识别和特征.
- 调查新型分离物的遗传和表型特性,包括抗菌素耐药性.
主要方法:
- 使用Sensititre,Vitek,API套件,MALDI-TOF和Illumina MiSeq.进行表型和遗传表征.
- 基因基因分析基于16S rRNA基因测序和与相关物种的平均核酸标识 (ANI) 比较.
主要成果:
- 该分离物被确定为一种名为Pseudocitrobacter limerickensis的新物种,显示99.7%的16S rRNA与Pseudocitrobacter corydidari.
- 基因组分析揭示了包括Klebsiella pneumoniae carbapenemase在内的显著抗微生物耐药性基因 (ARG) 的存在,使其对多种抗生素类别产生耐药性.
- 现型检测证实了抗菌素耐药性概况.
结论:
- 伪菌 (Pseudocitrobacter limerickensis) 在ARG形状和殖民中显示出与P. corydidari的显著分歧,这表明了不同的进化.
- 患者被殖民,没有感染,不需要治疗.
- 这种新物种的基因组数据已提交给GenBank.
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