一个电极阻抗感知神经刺激器IC,实现低功耗和快速充电平衡
Yawen Shi1, Quanbei Chang1, Xiao Liu2
1School of Information Science and Technology, Fudan University, Shanghai 200433, China; State Key Laboratory of Integrated Chips and Systems, Fudan University, Shanghai 201203, China.
Journal of neuroscience methods
|January 12, 2024
概括
本研究介绍了植入神经刺激器的两种新型电荷平衡方案,提高了电极-组织接口的安全性和效率. 新方法为神经障碍患者提供更快,更强大的神经刺激.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 电气工程 电气工程
背景情况:
- 植入的神经刺激对于恢复神经功能损失在患有神经障碍的患者至关重要.
- 通过电荷平衡保持电极-组织接口安全性对于长期使用神经刺激器至关重要.
- 现有的电荷平衡系统往往缺乏效率和速度,需要改进的集成电路设计.
研究的目的:
- 为神经刺激器集成电路提出和评估两种新的电荷平衡方案.
- 通过优化电荷平衡来提高可植入神经刺激的安全性和效率.
- 开发一个阻抗感知电荷平衡系统,运行更快,耗电更少.
主要方法:
- 开发了两个新的电荷平衡方案:一个基于接入电阻 (RS),另一个基于电极间阻抗的双层电容 (CDL).
- 采用180nm CMOS 工艺实现了一个阻抗感知刺激器应用特定集成电路 (ASIC).
- 使用布局后模拟来评估电荷平衡性能和功耗.
主要成果:
- 基于RS的方案实现了无需额外放电阶段的适应性阳极阶段电荷平衡,从而获得更快的补偿.
- 基于CDL的方案完全在模拟领域进行电荷平衡,避免了ADC和数字计算的需要,从而提高了速度和功率效率.
- 模拟显示电压偏差显著降低至2.64mV (基于RS) 和-1.39mV (基于CDL).
- 基于CDL的充电平衡器在400Hz的刺激速率下产生了2.46μW的低额外功率开销.
结论:
- 拟议的基于RS和基于CDL的电荷平衡系统显著提高了神经刺激器集成电路的安全性和效率.
- 基于模拟域CDL的方案为现有的数字域方法提供了更快,更节能的替代方案.
- 这些进步有望提高可植入神经刺激装置的长期性能和可靠性.
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