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双甲暴露刺激前列腺纤维化通过外引发的表皮质变化

Qingqin He¹, Congyue Xu², Jing Guo³

¹Department of Pharmacy, School of Medicine, Jianghan University, Wuhan, Hubei Province, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|January 12, 2024

概括

双甲 (BPA) 暴露导致前列腺纤维化,通过改变通过外体细胞的细胞通信. 这种环境内分泌干扰物促进原沉积和上皮细胞的变化,有助于良性前列腺增生症的进展.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
内分泌学在内分泌学.
细胞生物学细胞生物学

背景情况:

纤维化是良性前列腺激增症 (BPH) 进展和下泌尿道症状的核心原因.
已知双甲 (BPA) 是一种环境内分泌干扰物 (EED),可导致前列腺缺陷.

研究的目的:

用体外模型研究BPA对前列腺纤维化的影响.
阐明外体在BPA诱导的前列腺变化中的作用.

主要方法:

利用暴露于BPA的小鼠和人类前列腺细胞模型.
分析了原沉积和氧的度.
进行了高通量RNA测序和功能丰富分析.

主要成果:

由BPA诱导的前列腺纤维化,由增加的原和氧证明.
暴露于BPA的树皮纤维细胞的外基因组促进了上皮细胞-介质细胞过渡.
RNA测序揭示了改变的mRNA,lncRNA和circRNA参与细胞相互作用和HIF-1信号传递.

结论:

外体细胞介导细胞间通信,有助于BPA在前列腺上产生亲纤维性作用.
通过外体介导的信号传递,BPA暴露会触发上皮细胞的变化和纤维化.
了解这些机制对于管理BPH进展至关重要.

关键词:

双 A 是一种双.皮质 - 介质细胞过渡.外基因组是外基因组的组成部分.前列腺纤维化前列腺纤维化.

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