在1型和2型糖尿病患者中,原发性开角玻璃眼与糖尿病视网膜病变的关联:一项大型全球数据库研究
Muhammad Z Chauhan1, Abdelrahman M Elhusseiny1, Krishna S Kishor2
1Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Ophthalmology
|January 12, 2024
概括
初级开角玻璃眼 (POAG) 在1型糖尿病 (T1DM) 和2型糖尿病 (T2DM) 患者中显著增加患糖尿病视网膜病变 (DR) 的风险. 这凸显了需要仔细查和管理的糖尿病患者与玻璃眼.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病视网膜病变 (DR) 是导致失明的主要原因.
- 初级开角青光眼 (POAG) 是一种常见的青光眼形式.
- 糖尿病患者中POAG和DR风险之间的关系需要进一步调查.
研究的目的:
- 评估初级开角青光眼 (POAG) 与患糖尿病视网膜病变 (DR) 的风险之间的关联.
- 评估1型糖尿病 (T1DM) 和2型糖尿病 (T2DM) 患者的这种相关性.
主要方法:
- 使用TriNetX研究网络数据库进行了一项回顾性队列研究.
- 44,359名糖尿病患者和POAG患者与4,393,300名患有DM但没有青光眼的患者进行了比较.
- 倾向性得分与协调队列匹配,每组为39,680名患者,数据分析时间为2005年1月1日至2023年1月1日.
主要成果:
- 在10年后,T1DM和POAG患者的任何DR风险增加了4.12倍,扩散性DR风险增加了7.02倍 (PDR).
- 患有T2DM和POAG的患者在10年后,任何DR的风险增加了2.47倍,PDR的风险增加了3.82倍.
- 十年后,在POAG组中,DR的累积发病率明显高 (5.45%) 与非玻璃眼组 (2.12%) 相比.
结论:
- 在T1DM和T2DM患者中,POAG和DR发育之间存在显著的关联.
- 警的查和全面的管理对于患有青光瘤的糖尿病患者来说至关重要,以减轻DR风险.
- 需要进一步的研究来阐明潜在的因果机制.
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