经FDA批准的小分子蛋白激酶抑制剂的特性:2024年更新
1Blue Ridge Institute for Medical Research, 221 Haywood Knolls Drive, Hendersonville, NC 28791, United States.
Pharmacological research
|January 12, 2024
概括
蛋白质激酶抑制剂是关键的药物标,目前有80种FDA批准的药物. 本综述详细介绍了它们的物理化学特性,有助于开发针对癌症和炎症疾病的新向疗法.
科学领域:
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 蛋白激酶是细胞过程的关键调节者,它们的失调与许多疾病有关,特别是癌症.
- 准蛋白激酶已经成为21世纪药物开发的主要重点.
- 目前有80种FDA批准的针对蛋白激酶的药物,在2023年有7种新的批准.
研究的目的:
- 审查所有80种FDA批准的小分子蛋白激酶抑制剂的物理化学特性.
- 为酶向疗法领域的研究人员和药物开发人员提供全面的资源.
主要方法:
- 80种FDA批准的蛋白激酶抑制剂的物理化学数据的汇编和总结.
- 基于酶向的抑制剂的分类 (氨酸/氨酸,双重特异性,非受体氨酸,受体氨酸).
- 对药物应用的分析,包括癌症和炎症性疾病.
主要成果:
- 在已批准的80种药物中,69种药物用于治疗瘤,6种药物用于治疗炎症.
- 七种新的蛋白质激酶抑制剂在2023年获得FDA批准,用于治疗各种癌症和白发性脱发症.
- 大多数批准的激酶抑制剂是口服的,只有少数例外.
结论:
- 美国食品和药物管理局批准的蛋白激酶抑制剂的风景是多样化和扩展,在瘤学和炎症中具有重要应用.
- 了解这些抑制剂的物理化学特性对于优化药物设计和预测治疗疗效至关重要.
- 这一综述为现有的酶向药物的物理化学特征提供了宝贵的参考.
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