患有1型糖尿病风险增加的婴儿中维生素D缺乏:POInT研究的二次分析
An Jacobs1, Maarten Warnants2, Veronika Vollmuth3
1Department of Pediatric Endocrinology and Diabetes, KU Leuven University Hospitals Leuven, Leuven, Belgium an.k.jacobs@gmail.com.
BMJ paediatrics open
|January 12, 2024
概括
维生素D不足在患1型糖尿病的高风险婴儿中很常见. 目前的治疗指南似乎无效,这表明需要增加维生素D补充剂,特别是在冬季.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 维生素D不足 (VDI) 是1型糖尿病 (T1D) 发展的潜在因素.
- 在高风险婴儿中调查VDI对于理解T1D病变的产生至关重要.
- 维生素D补充指南的局部变化可能会影响结果.
研究的目的:
- 评估高T1D遗传风险的婴儿中VDI的患病率和持续性.
- 在一次性预防研究中评估当前VDI治疗方案的有效性.
- 为这个脆弱人群提供维生素D补充策略的潜在调整信息.
主要方法:
- 在POINT研究中,招募了4-7个月龄的婴儿,这些婴儿具有T1D的高遗传风险.
- 维生素D水平从入学开始被监测到3岁.
- VDI被定义为<30 ng/mL,并按照当地指导方针进行治疗;在下一次访问时恢复所需的水平≥30 ng/mL.
主要成果:
- 在1050名婴儿的访问中,VDI在24.7%的访问中被观察到.
- 超过46%的VDI病例在随后的访问中没有得到解决.
- 风险因素包括冬季季节,体重较高,年龄较大和国家 (英格兰);冬季VDI增加了无法恢复的风险.
结论:
- 维生素D缺乏症常见于患T1D风险较高的婴儿.
- 目前对该群体的VDI治疗指南似乎不够.
- 建议增加维生素D补充剂,特别是在冬季和VDI诊断后.
关键词:
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