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洛拉塔丁对菲尔格拉斯蒂姆诱导的骨疼痛的作用
Jeannette Mazzola1, Pamela Hennon2, Kellie Peine3
1From the Taussig Institute, Cleveland Clinic, Beachwood, Ohio.
概括
乙氨基,NSAIDs和洛拉塔丁有效地管理乳腺癌患者的佩格菲拉斯蒂姆诱导的骨疼痛. 乙氨基被评为最有效的,其次是洛拉塔丁,然后是NSAIDs,尽管洛拉塔丁提供每天一次的剂量.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 佩格菲尔格拉斯蒂姆用于预防接受化疗的乳腺癌患者的中性质减退.
- 严重的骨疼痛是佩格菲尔格拉斯蒂姆的常见副作用,影响患者的生活质量.
- 目前用于管理佩格菲尔格拉斯蒂姆诱导的骨疼痛的建议包括NSAIDs,乙氨基,阿片类药物和抗胰岛素药物,对比研究有限.
研究的目的:
- 为了比较洛拉塔丁与乙氨基或NSAIDs在乳腺癌患者中管理佩格菲尔格拉斯蒂姆诱导的骨疼痛的感知有效性.
- 探索患者如何了解和获取对佩格菲尔格拉斯蒂姆诱导的骨疼痛的治疗方法.
- 解决关于常见疼痛管理策略的比较疗效的文献上的差距.
主要方法:
- 采用了横截面研究设计.
- 从66名接受 pegfilgrastim 化疗的成年女性乳腺癌患者收集了数据.
- 使用调查方法收集有关药物使用和感知有效性的信息.
主要成果:
- 骨头疼痛发生在研究样本的45%.
- 近70%的患者单独或组合使用乙氨基,NSAID或洛拉塔丁来预防骨疼痛.
- 患者将所有药物评为有效药物,其中乙氨基被认为比洛拉塔丁更有效,而洛拉塔丁比NSAID更有效.
结论:
- 乙氨基,NSAIDs和洛拉塔丁是治疗佩格菲尔格拉斯蒂姆诱导的骨疼痛的可访问和负担得起的选择.
- 洛拉塔丁提供方便的每日一次剂量计划,副作用最小,与NSAID和乙胺不同.
- 进一步的研究,包括随机对照试验,对于确定这些药物的最佳使用,时间和持续时间至关重要.
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