肺癌查COPD患者:潘普隆纳-IELCAP经验
Juan P de-Torres1, Ana Belén Alcaide2, Arancha Campo1
1Pulmonary Department, Clínica Universidad de Navarra, Pamplona, Spain; Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
慢性阻塞性肺部疾病 (COPD) 患者的肺癌查使肺癌 (LC) 的早期诊断成为可能. 这种方法导致了与治愈治疗相容的生存率,突出了其在这个高危人群中的有效性.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 放射学 放射学是指放射学
背景情况:
- 全球阻塞性肺病倡议 (GOLD) 的指导方针建议对慢性阻塞性肺病 (COPD) 患者进行肺癌查.
- 然而,关于这种特定高风险人群的查结果的数据有限.
- 这项研究解决了对COPD患者肺癌查有效性的证据需求.
研究的目的:
- 评估COPD患者使用低剂量胸部断层扫描 (LDCT) 的肺癌查是否有助于早期肺癌 (LC) 诊断.
- 评估通过查获得的COPD患者早期LC诊断是否与可接受治愈治疗的生存率相关.
主要方法:
- 一个特有后期的探索性分析参与者从潘普隆纳国际早期肺癌行动计划 (P-IELCAP).
- 选择标准包括GOLD定义的阻塞模式 (支气管扩展后FEV<0.70) 的参与者.
- 分析涉及描述患有LC的参与者的特征和生存率,使用Cox比例分析来识别LC诊断预测因素.
主要成果:
- 该研究分析了865名患者 (77%是男性,93%是GOLD阶段1+2) 在102±63个月内.
- 肺癌发病率在基线为2.6%,年诊断率为0.68%.
- 早期瘤 (74%) 主要存在,平均存活时间为139个月. 累积的烟草暴露,FEV1%,以及肺气预测了LC诊断. 观察到第二次原发性肺癌和复发,生存率有利.
结论:
- 选择高风险COPD参与者的肺癌查可以在早期诊断肺癌.
- 已识别的早期肺癌表明了与治疗干预相容的生存结果.
- 在COPD患者群体中,LDCT查是检测肺癌在可治愈阶段的宝贵工具.
更多相关视频
08:14MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
相关概念视频
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
COPD: Management Using Bronchodilators and Corticosteroids
Chronic Obstructive Pulmonary Disease-I: Introduction
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Pulmonary Function Tests
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
