在患有固体癌症的患者中,可能的肉类与全因死亡率的关联:全国性的多中心队列研究
Liangyu Yin1, Chunhua Song2, Jiuwei Cui3
1Department of Clinical Nutrition, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing 400042, China; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
The journal of nutrition, health & aging
|January 12, 2024
概括
可能的sarcopenia (PS) 是固体癌症患者死亡率的强有力的预测因素. 早期评估PS可以帮助缓解过早死亡和改善癌症治疗结果.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 临床诊断 临床诊断 临床诊断
背景情况:
- 萨尔科佩尼亚是一种临床疾病,其特征是逐渐和普遍的骨肌肉强度,质量和功能.
- 可能的肉症 (PS) 作为一种查工具,用于在资源有限的环境中早期检测和干预.
- 早期识别PS对于管理癌症患者和改善他们的预后至关重要.
研究的目的:
- 为了研究可能的肉类 (PS) 与患有固体癌症的患者全因死亡率之间的关联.
- 评估PS在预测该患者群体内的死亡率方面的预后价值.
主要方法:
- 进行了一项追溯观察性研究,涉及13736名患有16种类型固体癌症的患者.
- PS被定义为低的小腿周长和低的手握强度.
- 使用哈雷尔的C指数评估预后值,并使用多变量调整的危险比率 (HRs) 分析死亡风险.
主要成果:
- 与低小腿周长 (0.541) 或低手握强度 (0.542) 单独相比,PS显示了更高的哈雷尔C指数 (0.549).
- 在多变量模型中,PS显著与全因死亡风险增加有关 (HR = 1.190).
- 在各种敏感性分析和子组中,PS与死亡率之间的关联仍然很强.
结论:
- 可能的sarcopenia独立且稳健地预测了固体癌症患者的全因死亡率.
- 将PS评估纳入常规癌症护理可以提供有价值的预后信息.
- 这种方法可以有助于缓解与肉症相关的过早死亡,并优化患者管理.
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